KIAMO - Killifish Immune Ageing MultiOmics

Please select (or erase and type) the gene you would like to search for:

Gene Symbol

Filter the gene list based on proteomics expression change with age:

Increase with age in kidney marrow

Decrease with age in kidney marrow

Significant change with age in kidney marrow

Increase with age in plasma

Decrease with age in plasma

Significant change with age in plasma

* Click on the tSNE plot to display the cell type annotations.

* Normalized expression: Corrected for the library size & log normalized.

* All data were generated using GRZ-AD strain Turquoise killifish. Proteomics data include 5 x 7-week-old (labelled young), and 5 x 16-week-old (labelled old) fish, whereas scRNAseq data include 2 x 8-week-old (labelled young) and 3 x 21-week-old (labelled old) fish.

* For detailed instructions and an example use case, please visit https://github.com/mdonertas/KIAMO/wiki

* For detailed information about the data and analysis, please see our paper: Spontaneous onset of cellular markers of inflammation and genome instability during aging in the immune niche of the naturally short-lived turquoise killifish (Nothobranchius furzeri) Gabriele Morabito, Handan Melike Dönertas, Luca Sperti, Jens Seidel, Aysan Poursadegh, Michael Poeschla, Dario Riccardo Valenzano bioRxiv 2023.02.06.527346; doi: https://doi.org/10.1101/2023.02.06.527346